碘131 与抗甲状腺药物治疗甲亢的临床疗效比较

目的:探讨碘131(I131)和抗甲状腺药物治疗甲亢的临床疗效对比,为临床提供参考依据。方法:选择2012年1月至2014年10月我院甲状腺功能亢进患者218例,按照随机数字表法分为观察组和对照组,每组各109例患者,观察组采用碘131治疗,对照组采用抗甲状腺药物治疗。比较治疗12个月后两组患者的临床疗效、复发率和并发症,采用酶联免疫吸附法检测治疗前后血清甲状腺激素水平。结果:治疗12个月后,观察组的有效率为92.66%明显高于对照组的69.72%,观察组的复发率为2.75%明显低于对照组的13.76%,差异均有统计学意义(P0.01)。观察组的心脏病、肝功能受损及血象降低等不良反应的发生率为7.34%明显低于对照组32.11%,差异有统计学意义(P0.01)。治疗后两组患者的血清甲状腺素(T4)、游离三碘甲状原氨酸(FT3)、三碘甲状原氨酸(T3)、促甲状腺激素(TSH)、游离甲状腺素(FT4)水平较治疗前降低,且观察组的降低幅度优于对照组,差异均有统计学意义(P0.05)。结论:碘131治疗甲亢可提高临床疗效,降低复发率,不良反应轻,可降低血清甲状腺激素水平,,值得推广应用。

Comparison of Clinical Efficacy of Iodine 131 and Antithyroid Drugs in Treatment of Hyperthyroidism

Objective:To study the comparison of clinical efficacy of iodine 131 (I131) and antithyroid drugs in treatment of hyperthyroidism, and to provide reference for clinical.Methods:Selected 218 cases of patients with hyperthyroidism in our hospital from January 2012 to October 2014, which were divided into observation group and control group according to random number table method, with 109 patients in each group. The observation group was treated with I131, and the control group was treated with antithyroid drugs. Compared the clinical efficacy, recurrence rate, complications of two groups after 12 months of treatment, and detected the levels of serumthyroid hormone by enzyme-linked immunosorbent assay before and after treatment.Results:After 12 months of treatment, the effective rate in observation group was 92.66%, which was obviously higher than 69.72% of control group, and the recurrence rate in observation group was 2.75%, which was obviously lower than 13.76% of control group,the differences were statistically significant(P<0. 01). The incidence rate of adverse reactions such as heart disease, liver function damage and decreasing hemogram in the observation group was 7.34%, which was lower than 32.11%of control group, the difference was statistically significant(P<0.01). The levels of serum thyroxine(T4), free three iodine thyroid original acid(FT3), three iodine thyroid original acid (T3), thyroid stimulating hormone(TSH) and free thyroid hormone (FT4) in two groups after treatment were lower than before treatment, and the reduction rate of the observation group was better than control group, the difference was statistically significant (P<0.01).Conclusion:The Iodine 131 treatment of hyperthyroidismis able to improve clinical efficacy, reduce the recurrence rate, adverse reactions, and also can reduce the levels of serum thyroid hormone, which is worthy of promotion and application.