卡维地洛对轻中度高血压患者血脂代谢的影响

目的:探讨卡维地洛对轻中度高血压患者血脂代谢的影响。方法:随机选取我院2012年1月~2015年1月收治的80例轻中度高血压患者为研究对象,将其分为观察组和对照组,观察组采用卡维地洛对其治疗,对照组给予美托洛尔治疗,比较两组的治疗效果、治疗前后血压、心率及血脂水平的变化。结果:观察组患者的治疗总有效率为90%,而对照组患者的治疗总有效率为72.5%,显著低于观察组,差异具有显著性(P0.05)。治疗后,两组患者的收缩压、舒张压和心率均较治疗前均降低,差异具有显著性(P0.05),但两组之间收缩压、舒张压相比差异不具有统计学意义,而观察组患者的心率显著高于对照组(P0.05)。治疗后,观察组总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL-C)水平均较治疗前显著降低,且低于对照组,而高密度脂蛋白(HDL-C)水平显著高于治疗前,且高于对照组,差异均具有统计学意义(P0.05)。结论:卡维地洛较美托洛尔可更有效治疗轻中度高血压患者,同时改善患者的血脂水平,且对患者心率的影响较小。

Effects of Carvedilol on the Lipid Metabolism of Patients with Mild toModerate Hypertension

Objective:To investigate the effects of carvedilol on the lipid metabolism of patients with mild to moderatehypertension.Methods:80 patients with mild to moderate hypertension admitted in our hospital from Jan. 2012 to Jan.2015 wererandomly selected and divided into the observation group and the control group. Carvedilol was given to the observation group, andmetoprolol was given to the control group. Then the clinical efficacy and changes of blood pressure, heart rate and blood lipid levelsbefore and after treatment were observed and compared between two groups.Results:The total efficacy of observation group was 90%,which was obviously higher than that of the control group(72.5%, P<0.05). The systolic pressure, diastolic pressure and heart rate of bothgroups after treatment were lower than those before treatment (P<0.05). The systolic pressure and diastolic pressure of both groups aftertreatment had no difference(P>0.05), but the heart rate of observation group was obviously higher than that of the control group(P<0.05).The levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) of observation were significantly lower thanthose before treatment, and lower than those of the control group, while the high density lipoprotein (HDL-C) was significantly higherthan that before treatment and the control group(P<0.05).Conclusion:Compared with Metoprolol, Carvedilol could more effectively treatpatients with mild to moderate hypertension and improve the blood lipid levels of patients, but had less impact on the heart rate.