早发冠脉三支病变患者血清ox-LDL、ApoB及ApoB/A1 水平变化及临床意义

目的:研究早发冠脉三支病变患者血清氧化低密度脂蛋白(ox-LDL)、载脂蛋白B(Apo B)、载脂蛋白A1(Apo A1)及Apo B/A1水平变化及临床意义。方法:选取2014年3月2015年3月我院收治的以心绞痛症状就诊患者185例,根据冠脉造影将患者分为研究组(早发冠脉三支病变103例)和对照组(冠脉正常82例),比较两组ox-LDL、Apo B、Apo A1及Apo B/A1水平,分析其与早发冠脉三支病变的关系。结果:研究组ox-LDL、Apo B及Apo B/A1水平显著高于对照组,两组比较差异具有统计学意义(P0.05),两组Apo A1水平比较无统计学意义(P0.05);Logistic回归分析显示:ox-LDL是早发冠脉三支病变的独立危险因素。结论:血清ox-LDL、Apo B及Apo B/A1水平与早发冠脉三支病变密切相关,ox-LDL是独立危险因素。

Patients with Early Three Coronary Lesions: Changes and Clinical Significance of Serumox-LDL, ApoB and ApoB/A1

Objective:To study the changes and clinical significance of serum oxidized low density lipoprotein (ox-LDL), apolipoproteinB (ApoB) and ApoB/A1 in patients with early three coronary lesions.Methods:A total of 185 patients with angina, who were admitted to Qionghai People''s Hospital from March 2014 to March 2015, were selected and divided into study group (n=103, with early three coronary lesions) and control group(n=82, with normal coronary) according to the coronary angiography results. The Ox-LDL, ApoB, ApoA1 and ApoB/A1 levels of two groups were compared, and their relationship with early three coronary lesions were analyzed.Results:The Ox-LDL, ApoB and ApoB/A1 levels of study group were significantly higher than those of control group(P<0.05), but there was no significant difference in the ApoA1 level between the two groups (P>0.05). Logistic regression analysis showed that Ox-LDL was the independent risk factor of early three coronary lesions.Conclusion:The levels of serum ox-LDL, ApoB and ApoB/A1 are closely related with early three coronary lesions, furthermore, Ox-LDL is an independent risk factor.