康柏西普联合激光光凝治疗糖尿病黄斑水肿43 例临床分析

目的:探讨康柏西普玻璃体腔注射联合激光光凝治疗糖尿病黄斑水肿的临床疗效及安全性。方法:收取2013年6月至2015年8月间我院收治的糖尿病黄斑水肿患者87例(87眼)作为研究对象,采用随机数字表法将其分为观察组及对照组,观察组43例(43眼)给予康柏西普玻璃体腔注射联合激光光凝治疗,对照组44例(44眼)给予单纯激光光凝治疗。对两组患者治疗前后视力(best corrected visual acuilty,BCVA)、视网膜厚度(central macular thickness,CMT)、临床疗效、并发症以及生活质量进行观察与比较。结果:治疗前两组患者BCVA、CMT均无显著差异,治疗后两组BCVA、CMT均有所提高,同时间点观察组明显高于对照组,差异有统计学意义(P0.05)。观察组治疗后6个月视力提高率为81.40%,对照组为13.64%,观察组远高于对照组,差异有统计学意义(P0.05)。观察组患者共有3例出现一过性眼压升高,对照组共有2例患者出现一过性眼压增高,两组相较无统计学差异(P0.05)。观察组生活质量显著高于对照组,差异有统计学意义(P0.05)。结论:康柏西普玻璃体腔注射联合激光光凝治疗糖尿病黄斑水肿具有良好的疗效及安全性,有利于患者生活质量提高,值得临床推广应用。

Clinical Analysis of Conbercept Combined with Macular laser Gird Photocoagulation for 43 Patients with Diabetic Macular Edema

Objective:To explore the clinical effect and safety of intravitreal injection of conbercept combined with macular laser gird photocoagulation for diabetic macular edema.Methods:87 patients (87 eyes) with diabetic macular edema accepted in our hospital from June 2013 to August 2015 were randomly divided into observation group and control group. 43 patients (43 eyes) in observation group were given conbercept intravitreal injection combined macular laser gird photocoagulation, and 44 patients (44 eyes) in control group were given macular laser gird photocoagulation. Then best corrected visual acuity (BCVA), central macular thickness (CMT), clinical effect, complications and life quality of two groups were observed and compared.Results:The BCVA and CMT of two groups had no statistically difference before treatment,and both of them were increased after treatment, and it was higher observation group than that of control group with statistically significance (P<0.05). The visual acuity improve rate of observation group was 81.40 %, which was higher than 13.64 %of control group with statistically significance (P<0.05). There were 3 cases with temporary high IOP in observation group and 2 cases in control group, which had no statistically significance between two groups (P>0.05). The life quality of observation group was higher than that of control group with statistically difference (P<0.05).Conclusion:Intravitreal injection of conbercept combined with macular laser gird photocoagulation has good effect and safety in the treatment of diabetic macular edema, which can improve life quality and worth of clinical application.