甲状腺功能5 项检测在妊娠期妇女中的应用

目的:分析甲状腺功能5项检测在妊娠期妇女中的应用价值,为制定妊娠期妇女的甲状腺功能指标的参考值范围提供依据。方法:选取2013年8月~2014年12月我院收治的826例健康妊娠妇女(实验组)与794例非妊娠育龄妇女(对照组)为研究对象。采用电化学发光法检测甲状腺功能5项指标,即三碘甲腺原氨酸(TT3)、甲状腺素(TT4)、促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4),比较两组甲状腺功能异常率,并比较5项指标在妊娠早、中、晚期妇女与对照组中的差异。结果:(1)实验组甲状腺功能异常的发生率(39.10%)显著高于对照组(17.63%),差异有统计学意义(P0.05);(2)实验组FT4、TT4水平随着妊娠期的进展逐渐降低,TSH水平逐渐升高,且均低于对照组水平,差异有统计学意义(P0.05);而各妊娠期FT3、TT3水平比较差异无统计学意义,但均略低于对照组(P0.05)。结论:甲状腺功能5项指标检测应作为妊娠期妇女的孕期必查项目之一,且制定早、中、晚期妊娠期妇女的甲状腺功能5项指标参考值范围十分必要。

Application of 5 Indexes Detection of Thyroid Function in Pregnant Women

Objective:To analyze the application value of 5 indexes detection of thyroid function in pregnant women, in order to provide a basis for setting the reference value range of thyroid function indexes in pregnant women.Methods:A total of 826 cases of healthy pregnant women (as experimental group), who were admitted to Chengdu Women and Children Center Hospital from August 2013 to December 2014, and 794 cases of non pregnant and childbearing age women(as control group) were chosen as research subjects. The 5 indexestriiodothyronine, (TT3), tetraiodothyronine(TT4), thyroid-stimulating hormone(TSH), free three iodine thyroid gland(FT3) and free thyroxine (FT4)] of thyroid function of all the subjects were detected by chemiluminescence method, The abnormal rate of thyroid function in the two groups was compared, and the differences of 5 indexes in the early, middle and late stages of experimental group were compared with control group.Results:(1)The abnormal rate (39.10%) of thyroid function in the experimental group was significantly higher than that(17.63%) of control group, the difference was statistically significant(P<0.05); (2)The levels of TT4 and FT4 in experimental group were gradually decreased along with the development of pregnancy, while the level of TSH was gradually increased, which were all lower than control group, the differences were statistically significant (P<0.05); And the levels of FT3 and TT3 in different pregnancy stages had no significance, but they were slightly lower than control group (P>0.05).Conclusion:5 indexes detection of thyroid function should be used as one of the must check items of pregnant women, and it is necessary to set the reference value range of these 5 indexes for early, middle and late stages detection.