腔隙性和非腔隙脑梗塞患者的血压差异研究

目的:比较腔隙性(LI)与非腔隙性(NLI)脑梗塞患者血压变化,评价血压与腔隙性脑梗塞的相关性。方法:选取在我院住院治疗的249例急性脑梗塞患者,根据不同亚型将患者分为腔隙性脑梗塞组(LI组,n=187)与非腔隙性脑梗塞组(NLI组,n=62),比较两组患者血压差异,采用线性相关分析与cox相关分析评估血压与脑梗塞及其危险因素的相关性。结果:LI组患者入院3天收缩压、舒张压显著高于NLI患者组,差异有统计学意义(分别P=0.003,P=0.009);线性回归分析表明,入院时收缩压、入院第3天收缩压、入院第3天舒张压与LI显著相关(均P0.05);cox单因素与多因素分析表明,入院第3天收缩压与LI显著相关(分别P=0.009与P=0.006),与其他协变量不相关(均P0.05)。而患者出院时血压与m RS或NIHSS不相关(分别P=0.788和P=0.898)。结论:与相同严重程度NLI患者比较,LI患者高血压与LI独立相关。LI患者血压显著高于NLI患者,二者差异虽与临床疾病严重程度无关,但很可能是患者发生急性脑梗塞的根本原因。

Differences in Blood Pressure between Lacunar Infarction Patients and Non-lacunar Infarction Patients

Objective:To compare the differences in blood pressure (BP) between lacunar infarction (LI) patients and Non-lacunar Infarction (NLI) patients, and to evaluate the correlation between BP and LI.Methods:A total of 249 patients of acute cerebral infarction were included. All patients were divided into lacunar infarction group (LI group, n=187) and non-lacunar infarction group (NLI group, n=62) according to the different subtypes of lacunar infarction. Compared BP differences between the two groups of patients. Evaluated the association between BP and infarction and risk factors by Linear correlation analysis and Cox correlation analysis.Results:Patients in LI group had significantly higher systolic and diastolic BP than those in NLI patients group within 3 days admitted to hospital, and the difference was statistically significant (respectively P=0.003, P=0.009). The linear regression analysis showed that systolic BP at admission, systolic and diastolic BP at 3d after admission were significantly associated with LI (all P <0.05). The Cox univariate and multivariate analysis showed that systolic BP at 3d after admission was significantly associated with LI (respectively, P=0.009 and P=0. 006), and other covariates were not correlated with LI (P>0.05). And the BP at discharge was irrelevant with NIHSS or mRS (respectively P=0.788 and P=0.898).Conclusion:Compared the NLI patients of the same severity, hypertension in LI patients were independently associated with LI. The BP of LI patients was significantly higher than that of the NLI patients. Although the difference was irrelevant with the clinical severity of the disease, it may be the root cause of patients to have acute cerebral infarction.