血必净注射液对重型颅脑损伤患者的神经保护及其机制研究

目的:探讨血必净注射液对重型颅脑损伤患者的神经保护作用及其机制。方法:将2012年1月至2014年12月我院收治的200例重型颅脑损伤患者分为研究组(100例)和对照组(100例),另选取100例同期在我院体检的健康者为正常组。对照组给予常规治疗,研究组在对照组基础上静脉滴注血必净注射液,治疗后第1天、第3天、第5天、第7天时观察各组TNF-α及IL-6水平变化。结果:对照组、研究组各时间点TNF-α及IL-6水平均高于正常组(均P0.05),且研究组的TNF-α及IL-6水平均低于对照组(均P0.05)。结论:血必净注射液对重型颅脑损伤患者的神经具有保护作用,其作用机制可能跟降低炎症反应有关。

Effect of Xuebijing Injection on Patients with Severe Traumatic Brain Injury

Objective:To investigate the effect and mechanism of Xuebijing injection on neuroprotection in patients with severetraumatic brain injury.Methods:A total of 200 patients with severe traumatic brain injury, who were treated in General Hospital ofJizhong Energy Fengfeng Group from January 2012 to December 2014, were divided into study group(n=100) and control group(n=100).Another 100 healthy people undergoing physical examinations in the same period were chosen as normal group. The control group wastreated with conventional therapy, while the study group was added Xuebijing injection on the basis of control group''s therapy. The levelsof TNF-alpha and IL-6 of the three groups 1 day, 3 days, 5 days and 7 days after treatment were observed.Results:The levels of TNF-alpha andIL-6 of control group and study group at each time point were higher than those of normal group (P<0.05), and the levels of TNF-alpha andIL-6 of the study group at each time point were lower than those of the control group ((P<0.05).Conclusion:Xuebijing injection has aprotective effect on the nerves of patients with severe traumatic brain injury. Its mechanismmay be related to reduce inflammation.