甲基强的松龙联合中剂量环磷酰胺治疗重症肌无力危象的临床效果

目的:探究甲基强的松龙联合中剂量环磷酰胺(CTX)治疗重症肌无力危象(MGC)的临床效果及安全性。方法:选取2012年1月~2015年6月在我院神经内科就诊的MGC患者90例,随机分为对照组(45例)和观察组(45例),对照组患者接受甲基强的松龙治疗,观察组采用甲基强的松龙联合中剂量CTX治疗。比较两组患者的临床疗效及不良反应的发生情况。结果:观察组患者呼吸困难消失时间、吞咽功能恢复时间和肢体无力症状改善时间均明显短于对照组(P0.05);观察组用药7 d内治疗有效率86.7%明显高于对照组(P0.05),肺部感染发生率20%,较对照组显著降低,差异均具有统计学意义(P0.05)。结论:甲基强的松龙联合中剂量CTX可有效提高MGC的治疗效果,促进患者早日康复,且肺部感染的发生率降低。

Analysis of the Clinical Effect of Methylprednisolone Combined with MediumDose Cyclophosphamide in the Treatment of Myasthenia Gravis Crisis

Objective:To explore the clinical effect of Methylprednisolone combined medium dose Cyclophosphamide (CTX) on myasthenia gravis crisis (MGC).Methods:90 cases of patients with MGC admitted in the department of neurology of our hospital from January 2012 to June 2015 were selected and randomly divided into the control group(45 cases) and the observation group(45 cases). The control group received treatment with Methylprednisolone, while the observation group was treated with Methylprednisolone combined with mediumdose CTX. The clinical efficacy was compared between two groups.Results:The average recovery time of respiratory difficulty, swallowing function and the improvement of limb weakness of observation group were significantly shorter than those of the control group (P<0.05). The effective rate in medication 7 days was 86.7%in the observation group, which was significantly higher than that of the control group(P<0.05), while the incidence of pulmonary infection was 20%in the observation group, which was significantly lower than that of the control group (P<0.05).Conclusion:Methylprednisolone combined with CTX could effectively improve the effect of MGC, and the incidence of pulmonary infection was low, it was worthy of popularization in clinic.