乌司他丁联合生长抑素治疗重症急性胰腺炎的临床疗效

目的:探讨重症急性胰腺炎(SAP)采用乌司他丁联合生长抑素治疗的临床疗效,为临床治疗提供参考。方法:按照随机数字表法将2011年5月~2013年5月我院收治的SAP患者分为观察组和对照组,两组均予乌司他丁进行治疗,观察组在此基础上联合生长抑素进行治疗,比较两组的临床治疗效果。结果:观察组疗效优于对照组,差异有统计学意义(P0.05),观察组腹痛缓解时间、血淀粉酶恢复时间、尿淀粉酶恢复时间、腹水消退时间少于对照组,差异有统计学意义(P0.05);治疗后的不良反应主要有恶心、呕吐,肠鸣音活跃,阵发性腹痛,大便次数增加以及头晕等症状,两组差异无统计学意义(P0.05),经对症治疗和综合护理后,不良反应得到不同程度的缓解。结论:SAP采用乌司他丁联合生长抑素治疗具有疗效好,不良反应少等特点,临床有重要参考价值。

Clinical Effect of Ulinastatin Combined with Somatostatin in Treatment of Severe Acute Pancreatitis

Objective:To investigate the clinical effects of ulinastatin combined with somatostatin in treatment of severe acute pancreatitis (SAP), and to provide reference for clinical treatment.Methods:Patients with SAP who admitted in our hospital from May 2011 to May 201 3 were divided into observation group and control group according to the random number table method. The two groups were treated with ulinastatin, the observation group were treated with somatostatin based on the treatment, and the clinical therapeutic effect of the two groups were compared.Results:Therapeutic effect of observation group was better than that of control group, and the difference was statistically significant (P<0.05); Abdominal pain relief time, recovery time of blood amylase, urine amylase recovery time, and ascites subsided time of the observation group were less than those of control group with statistical significance (P<0.05); Adverse reaction after treatment included nausea, vomiting, bowel sound active, paroxysmal abdominal pain, the stool frequency increased and dizziness, but there were no significant difference between the two groups (P>0.05). Adverse reactions were relieved in different degrees after symptomatic treatment and comprehensive care.Conclusion:Ulinastatin combined with somatostatin therapy for patients with severe acute pancreatitis has characteristics of good curative effect and less adverse reaction, and it has very important clinical reference value.