二甲基亚砜毒性研究

二甲基亚砜(Dimethyl sulfoxide DMSO)是一种含硫有机化合物,被誉为"万能溶剂",广泛用作溶剂和反应试剂。在医药工业中,DMSO可直接用作某些药物的原料及载体。DMSO本身有消炎止痛,利尿,镇静等作用,亦誉为"万灵药",常作为止痛药物的活性组分添加于药物之中。DMSO也是一种渗透性保护剂,能够降低细胞冰点,减少冰晶的形成,减轻自由基对细胞损害,改变生物膜对电解质、药物、毒物和代谢产物的通透性。DMSO作为组蛋白去乙酰化酶抑制剂(Histone Deacetylases-inhibitor HDACi)的一种,同样具有恢复组蛋白的乙酰化与去乙酰化平衡,抑制细胞程序性死亡,修复DNA双螺旋结构,抗放射性损伤,抗炎症反应及抗癌作用。鉴于其应用广泛,本文就其物理特性及毒性研究做一综述。

Dimethyl Sulfoxide Toxicity Studies

Dimethyl sulfoxide (DMSO) is a sulfur-containing organic compounds, known as "universal solvent", it is widely used as solvents and reagents. In the pharmaceutical industry, DMSO can be directly used as a raw material and a carrier of certain drugs. DMSO has anti-inflammatory analgesic, diuretic, sedative and other effects, also known as " panacea ", often used as an active component of analgesics being added to the drug. DMSO is a permeable protective agent, can reduce cell freezing point, reducing the formation of ice crystals, reduce free radical damage to cells, and change the permeability of membrane of electrolyte, drugs, poisons and metabolites. DMSO as one of the histone deacetylase inhibitor (Histone Deacetylases-inhibitor HDACi), also can restore histone acetylation and deacetylation balance, inhibit programmed cell death, repair DNA double helix structure, anti-radiation injury, anti-inflammatory and anti- cancer effects. Because of its widely applications, we do a reviewon its physical characteristic and toxicity studies.