双膦酸盐类药物致不良反应回顾性分析

目的:分析双膦酸盐类药物所致不良反应情况。方法:检索中国期刊全文数据库(CNKI)、万方数据库(Wan Fang)、中文科技期刊数据库(VIP)2004年1月至2013年8月国内有关双膦酸盐致不良反应的个案报道,按年龄、性别、原发病、药物名称、给药途径、不良反应发生时间、临床表现症状、治疗与转归等进行分类统计分析。结果:48例不良反应包括运动系统、消化系统、感官系统、循环系统、神经系统及全身性损害,高年龄段与女性发生率较高。结论:临床上应重视双膦酸盐类药物所致不良反应,坚持合理用药。

Retrospective Analysis on the Adverse Drug Reactions Induced by Diphosphonate Drugs

Objective:To investigate the situation of adverse drug reactions (ADR) induced by diphosphonate drugs.Methods:The cases of adverse drug reactions (ADRs) induced by diphosphonate reported in China fromJan, 2004 to Aug, 2013 were searched in CNKI, WanFang and VIP. Then they were classified and analyzed statistically according to age, gender, primary disease, drug name, administration, ADR reporting time, clinical symptoms, treatment and prognosis.Results:Forty-eight ADR cases involved the motion system, digestive system, sensory system, circulatory system, nervous system and systemic damage, with advanced age group and women showing the highest incidence.Conclusion:Diphosphonate drugs should be used with caution in the clinic for it may induce ADR.