Comparative mapping on the mouse X Chromosome defines a myotubular myopathy equivalent region |
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| Authors: | B de Gouyon A Chatterjee A Monaco N Quaderi S D M Brown G E Herman |
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| Institution: | (1) Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza 821T, Houston, TX 77030, USA, US;(2) Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA, US;(3) Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK, GB;(4) Department of Biochemistry and Molecular Genetics, St. Mary's Hospital, London W2 1PG, UK, GB |
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| Abstract: | The gene for X-linked myotubular myopathy (MTM1) has been localized to a 300-kb critical region in human Xq28 between IDS
and GABRA3. As part of an effort to clone this gene, we developed a YAC contig on the mouse X Chromosome (Chr) which includes
loci homologous to those within the human MTM1 critical region. The murine contig consists of 18 YACs and spans 2.5–3.0 Mb.
We have aligned the human and murine physical maps by isolating conserved mouse genomic fragments, including CpG islands and
trapped exons. We believe that the simultaneous isolation of genes from both mouse and human and continued comparative mapping
will prove helpful in the eventual identification of MTM1 and other genes in the region.
Received: 9 February 1996 / Accepted: 30 March 1996 |
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