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Effect of spontaneous twist on DNA minicircles |
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| Authors: | Medalion Shlomi Kessler David A Rabin Yitzhak |
| Affiliation: | † Department of Physics, Bar-Ilan University, Ramat-Gan, Israel ‡ Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel § Department of Biomedical Engineering, Northwestern University, Evanston, Illinois ¶ James Franck Institute, University of Chicago, Chicago, Illinois |
| Abstract: | Monte Carlo simulations are used to study the effect of spontaneous (intrinsic) twist on the conformation of topologically equilibrated minicircles of dsDNA. The twist, writhe, and radius of gyration distributions and their moments are calculated for different spontaneous twist angles and DNA lengths. The average writhe and twist deviate in an oscillatory fashion (with the period of the double helix) from their spontaneous values, as one spans the range between two neighboring integer values of intrinsic twist. Such deviations vanish in the limit of long DNA plasmids. |
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