New hepatoprotective coumarinolignoids from Mallotus apelta |
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| Authors: | Xu Jian-Fu Feng Zi-Ming Liu Jian Zhang Pei-Cheng |
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| Affiliation: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China. |
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| Abstract: | Three new coumarinolignoids, malloapelins A-C (1-3, resp.), together with three known coumarinolignoids, cleomiscosin A (4), cleomiscosin B (5), and 5'-demethylaquillochin (6), were isolated from the roots of Mallotus apelta MUELL.-ARG. Compounds 1-6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence. Compounds 3 showed promising hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells. |
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| Keywords: | Mallotus apelta Coumarinolignoids Malloapelins A – C Structure–activity relationship (SAR) Hepatoprotective activity |
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