Thyrotropin-releasing hormone and a homologous peptide in the reproductive system of the female rat and pig |
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| Authors: | A E Pekary J I Rosen F Geola C Vaillant B Sharp N Meyer J M Hershman |
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| Affiliation: | 1. Endocrinology Research Laboratory, Medical and Research Services, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073 USA;2. Department of Medicine, University of California, Los Angeles, California 90073 USA |
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| Abstract: | TRH and a TRH homologous peptide have been shown to occur throughout the female rat and pig reproductive systems by TRH radioimmunoassay, SP-Sephadex C-25 cation exchange chromatography, and parallel line analysis of the assays. The total amount of TRH and TRH homologous peptide immunoreactivity was highest in the oviducts followed by the ovary and then uterus. The concentration of TRH immunoreactivity in all reproductive organs of the rat fell gradually from one month of age. TRH and the TRH homologous peptide were not parallel on serial dilution and measurement in the same TRH radioimmunoassay. The rapid degradation of TRH by pig follicular fluid may explain the higher measured concentration of TRH homologous peptide compared to TRH not only in pig follicular fluid but also in the pig ovary as a whole. |
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| Keywords: | To whom reprint requests should be addressed. |
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