Specificity of the sensitivity of inbred mouse strains TPS, WR and CBA/LacY to the action of chemical mutagens

The cytogenetic effect of thioTEPA, ethyleneimine, mitomycin C, cyclophosphamide and phtorafurum in bone marrow cells of mouse strains TPS, WR, CBA/LacY was studied. Mice of the TPS strains were most sensitive to the action of all mutagens. Mice of the WR strain were sensitive to thioTEPA and phtorafurum but relatively resistant to mutagens which require metabolic preactivation, i. e. mitomycin C and cyclophosphamide. It was suggested to carry out the study of the cytogenetic activity of chemical compounds using the panel of TPS, WR, 101/H, C57BL/6Y, CBA/LacY strains.