Normal hematological and plasma biochemical parameters of the captive bonnet monkey (Maccaca radiata) |
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Authors: | S G Ramachandra V Ramesh H N Krishnamurthy N Ravindranath K Taranatha Shetty |
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Institution: | (1) Primate Research Laboratory, Indian Institute of Science, 560 012 Bangalore, India;(2) Department of Anatomy and Cell Biology, Georgetown University Medical Center, 2000 Washington D.C., USA;(3) National Institute of Mental Health and Neuroscience, 560 027 Bangalore, India |
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Abstract: | The bonnet monkey is being increasingly used as a model in biomedical research. However, unlike the rhesus monkey, very little
information on the hematological and biochemical characteristics of blood plasma is available. Comparative data on plasma
biochemical parameters vis-a-vis rhesus and human is essential for utilization of this species in biomedical research. Efforts
were made to determine selected serum enzymes, glucose, triglycerides, blood urea nitrogen, creatinine, total protein, albumin,
cholesterol, bilirubin, calcium, phosphorus, sodium, magnessium, potassium and total erythrocyte count, total leukocyte count,
hemoglobin, PCV, ESR, and differential leukocyte count in groups of juvenile and adult bonnet monkeys of both sexes. The monkeys
exhibited similar values for all the parameters in comparison to rhesus and human except for alkaline phosphatase. The value
for alkaline phosphatase was 3–5 fold higher when compared to concentrations seen in rhesus monkeys and human beings. The
investigation also describes the variations seen between adults and juveniles, as well as between the sexes. The data presented
is valuable for scientists using this species of monkey as a human surrogate model. |
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Keywords: | Bonnet monkey Macaca radiata Hematology Blood chemistry Juvenile and adult |
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