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Creating permissive microenvironments for stem cell transplantation into the central nervous system |
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| Authors: | Kim Howard Cooke Michael J Shoichet Molly S |
| Affiliation: | 1 Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8 2 Institute of Biomaterials and Biomedical Engineering, 164 College Street, Room 407, Toronto, ON, Canada, M5S 3G9 3 Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, Canada, M5S 3E5 4 Department of Chemistry, University of Toronto, 80St. George Street, Toronto, ON, Canada, M5S 3H6 |
| Abstract: | Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are promising because they can repopulate lost or damaged cells and tissues. However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues. This review provides an overview of tissue engineering strategies to improve stem cell therapies by providing a defined microenvironment during transplantation. The use of biomaterials for physical support, growth factor delivery, and cellular co-transplantation are discussed. Providing the proper environment for stem cell survival and host tissue integration is crucial in realizing the full potential of these cells in CNS repair strategies. |
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