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Rapid detection of blaIMP-6 by amplification refractory mutation system

Authors:	Kayama Shizuo Shigemoto Norifumi Kuwahara Ryuichi Onodera Makoto Yokozaki Michiya Ohge Hiroki Kato Fuminori Hisatsune Jyunzo Sugai Motoyuki

Institution:	^a Project Research Center for Nosocomial Infectious Disease, Hiroshima University, 1-2-3 Kasumi Minami-ku Hiroshima 734-8551, Japan ^b Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi Minami-ku Hiroshima 734-8551, Japan ^c Department of Surgery, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi Minami-ku Hiroshima 734-8551, Japan ^d Clinical Laboratory, Hiroshima University Hospital, 1-2-3 Kasumi Minami-ku Hiroshima 734-8551, Japan ^e Division of Infectious Diseases, Hiroshima University Hospital, 1-2-3 Kasumi Minami-ku Hiroshima 734-8551, Japan

Abstract:	Klebsiella pneumoniae resistant to almost all ß-lactams except imipenem designated as ISMRK (imipenem-susceptible meropenem-resistant Klebsiella) is emerging in Japan. All ISMRK carries bla_IMP-6 which differs from bla_IMP-1 by only a single nucleotide at position 640. We devised a rapid detection system of bla_IMP-6 by using ARMS PCR.

Keywords:	Klebsiella pneumoniae Metallo-ß -lactamase blaIMP-6 ARMS PCR
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