Twitches in the presence of ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid |
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| Authors: | C M Armstrong F M Bezanilla and P Horowicz |
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| Institution: | Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, U.S.A. |
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| Abstract: | Single muscle fibers continue to twitch for up to 20 min when immersed in ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA) solutions containing less than 10−8 M free calcium. Failure of the twitch results from reversible depolarization, which occurs after 15–20 min in EGTA. The results make it clear that external calcium or calcium in the transverse tubules play no essential part in action potential propagation or excitation-contraction coupling. |
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