Inhibition of an IUD-induced precocious luteolysis by prostaglandin E1 (PGE1) in sheep |
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| Authors: | C. Weems M. Huie R. Magness G. Hoyer G. Whysong |
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| Affiliation: | 2. Department of Animal, Dairy and Veterinary Sciences, UMC-48, Utah State University, Logan, Utah 84322, USA;3. Department of Pediatrics, School of Medicine, University of Texas Health Science Center, Dallas, Texas 75235, USA;4. Department of Pharmacology, School of Medicine, University of Arizona, Tucson, Arizona 85724, USA;5. Division of Agriculture, Arizona State University, Tempe, Arizona 85287, USA |
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| Abstract: | Fifteen ewes were assigned as they came into estrus to one of three randomized treatment groups: 1. Sham IUD + Vehicle, 2. IUD + Vehicle or 3. IUD + PGE1 in vehicle. An IUD was inserted adjacent to the luteal-bearing ovary on day 3 postestrus. Prostaglandin E1 (500 μg) in vehicle (Na2CO3) or vehicle was given intrauterine through an indwelling uterine cannula every four hours from day 3 postestrus until ewes returned to estrus. Precocious estrus was induced in both the sham IUD groups receiving vehicle. Prostaglandin E1 prevented an IUD-induced premature luteolysis based on daily concentrations of progesterone in peripheral blood and the interestrous interval. It is concluded that an IUD-induced premature luteolysis is not necessarily via physical distention by the IUD. It is also concluded that chronic intrauterine infusions of PGE1 can prevent an IUD-induced premature luteolysis. |
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| Keywords: | Reprint requests to C. W. Weems. |
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