| 干扰素-γ基因多态性与乙型肝炎病毒感染 |
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| 引用本文： | 孙向茹.干扰素-γ基因多态性与乙型肝炎病毒感染[J].生命的化学,2014(4):567-571. |
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| 作者姓名： | 孙向茹 |
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| 作者单位： | 南方医科大学附属何贤纪念医院生殖医学科 |
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| 摘 要： | 干扰素-γ(interferon-γ,IFN-γ)是重要的辅助型T细胞-1型(type-1 helper T-cell,Th1)细胞因子,它作为抗原提呈细胞和淋巴细胞增殖、分化的调节剂,参与机体的炎症反应和抗病毒免疫。细胞因子的基因多态性影响细胞因子的表达水平,导致个体间免疫反应的差异,最终影响感染后的发展趋势和临床转归。本文主要就IFN-γ基因多态性与乙型肝炎病毒(hepatitis B virus,HBV)自发清除、感染慢性化、肝硬化、肝癌及抗病毒治疗的相关研究进行评述。
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| 关 键 词： | 乙型肝炎病毒 干扰素-γ 单核苷酸多态性 |
Relationship between interferon-γ gene polymorphisms and hepatitis B virus infection |
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| SUN Xiangru.Relationship between interferon-γ gene polymorphisms and hepatitis B virus infection[J].Chemistry of Life,2014(4):567-571. |
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| Authors: | SUN Xiangru |
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| Institution: | SUN Xiangru (Institute of Reproductive Medicine, Hexian Memorial affiliated Hospital of Southern Medical University, Guangzhou 511400, China) |
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| Abstract: | Interferon-γ （IFN-γ） is an important type-1 helper T-cell （Thl） cytokine. As a modulator of prolif-eration and differentiation of antigen presenting cell and lymphocytes, it participates in the inflammation andantiviral immune response to infection. Genetic polymorphisms determine the level of cytokines and result indifferent level between individuals, which influence the progression and clinical outcome of infection. Thisreview has summarized the studies on IFN-y gene polymorphisms, regarding spontaneous hepatitis B virus（HBV） elimination, susceptibility to chronic HBV infection, course of HBV-related liver disease （cirrhosis,hepatocellular carcinoma） as well as response to antiviral therapy |
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| Keywords: | hepatitis B virus （HBV） IFN-γ single-nucleotide polymorphism |
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