Par-4 inducible apoptosis in prostate cancer cells |
| |
Authors: | Gurumurthy Sushma Rangnekar Vivek M |
| |
Institution: | Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA. |
| |
Abstract: | Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy. |
| |
Keywords: | Par‐4 prostate apoptosis |
本文献已被 PubMed 等数据库收录! |
|