内质网应激与糖尿病动脉粥样硬化

动脉粥样硬化是糖尿病常见的并发症,80%的糖尿病患者死于动脉粥样硬化。近年来内质网应激在糖尿病动脉粥样硬化发生、发展过程中的作用受到了广泛关注。本文就内质网应激及其在糖尿病促发动脉粥样硬化中的作用机制作一概述。

Endoplasmic reticulum stress and diabetic atherosclerosis

Atherosclerosis is the common complication of diabetes,and 80% of patients with diabetes die from atherosclerosis.A vast amount of research has gone into understanding the mechanisms by which diabetes promotes atherosclerosis,and recent findings have shed light on endoplasmic reticulum stress (ERS) in the pathogenesis of atherosclerosis.This review summarizes recent research progress of ERS and the mechanisms of ERS in the development and progression of diabetic atherosclerosis.