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Synchrotron X-ray imaging via ultra-small-angle scattering: principles of quantitative analysis and application in studying bone integration to synthetic grafting materials |
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| Authors: | Sérgio L Morelhão Paulo G Coelho Marcelo G Hönnicke |
| Institution: | 1. Instituto de Física, Universidade de S?o Paulo, S?o Paulo, SP, Brazil 2. Department of Biomaterials and Biomimetics, New York University, New York, NY, USA 3. NSLS II, Brookhaven National Laboratory, Upton, NY, 11973, USA |
| Abstract: | Optimized experimental conditions for extracting accurate information at subpixel length scales from analyzer-based X-ray imaging were obtained and applied to investigate bone regeneration by means of synthetic β-TCP grafting materials in a rat calvaria model. The results showed a 30% growth in the particulate size due to bone ongrowth/ingrowth within the critical size defect over a 1-month healing period. |
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