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Novel lactam NK1 antagonists with anti-emetic activity |
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| Authors: | Hollingworth Gregory J Carlson Emma J Castro José L Chicchi Gary G Clark Natalie Cooper Laura C Dirat Olivier Salvo Jerry Di Elliott Jason M Kilburn Ruth Kurtz Marc M Rycroft Wayne Tattersall F David Tsao Kwei-Lan Swain Christopher J |
| Affiliation: | Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. greg_hollingworth@merck.com |
| Abstract: | A series of 4,4-disubstituted cyclohexylamine NK(1) antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model. |
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