Trace elements profile in the blood of Huntington’ disease patients |
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| Institution: | 1. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, via Bologna 148, 10154 Torino, Italy;2. University of Torino, Department of Medical Sciences, 10126 Torino, Italy;3. Città della Salute e della Scienza University Hospital, Medical Genetics Unit, 10126 Torino, Italy;1. Research Center for Health Sciences and Technologies, Semnan University of Medical Sciences, Semnan, Iran;2. Department of microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran;3. Department of Biology, Science and Reserch Branch, Islamic Azad University, Tehran, Iran;4. Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;5. Center of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria;6. School of Pharmacy, Faculty of Sciences, University of Rome Tor Vergata, Rome, Italy;7. Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;8. Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;9. Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;2. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha, 410078, PR China;3. Department of Clinical Laboratory Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;4. Department of General Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, PR China;5. Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, PR China;6. National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, PR China;7. College of Chemistry & Chemical Engineering, Central South University, Changsha, 410083, PR China;8. Department of Oncology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, PR China;1. Department of Neurology, University Medical Center, Göttingen, Germany;2. Research Unit Analytical BioGeoChemistry, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany;3. German Center for Neurodegenerative Diseases, University of Tübingen, Germany;4. Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany;5. Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany;6. DZNE, German Center for Neurodegenerative Diseases, Göttingen, Germany;7. Center for Biostructural Imaging of Neurodegeneration (BIN), University of Göttingen Medical Center, Göttingen, Germany;8. Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, München, Germany |
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| Abstract: | Huntington’ disease (HD) is an autosomal dominant neurodegenerative disease characterized by progressive motor, psychiatric, and cognitive deterioration. HD is, together with spinocerebellar ataxias, spinobulbar muscular atrophy and dentatorubral-pallido- luysian atrophy, one of the nine disorders caused by an expansion of glutamine residues in the causative protein where the polyglutamine expansion cause aberrant protein folding. Since an excessive metal’s accumulation in organs may induce protein misfolding and oxidative stress, we have studied the blood concentration of essential (Cr, Co, Cu, Fe, Mn, Mo, Ni, Se, Zn) and nonessential (As, Cd, Sb, Sn, V) trace elements in HD patients.We found increased levels of the essential elements iron, chromium, selenium and zinc and of the nonessential element arsenic in the blood of HD patients.Since alteration in metals homeostasis may contribute to the pathogenesis of neurodegenerative disease and could eventually constitute a target for therapy, we may suggest the utilize of the blood metal profile as a further in vivo tool to study and characterize Huntington disease. |
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| Keywords: | HD Blood Neurodegeneration Metals |
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