Inflammation factors and element supplementation in cancer |
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| Institution: | 1. Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain, C/Sant Antoni M. Claret 167, 08025 Barcelona, Spain;2. Molecular Biology and Biochemistry Department, Universitat Autònoma de Barcelona (UAB) Faculty of Medicine, Building M. Cerdanyola del Vallès, Spain;3. Biochemistry Department, Hospital de la Santa Creu i Sant Pau Barcelona, C/Sant Quintí 89, 08026 Barcelona, Spain;1. Department of Toxicology, Faculty of Pharmacy, Medical University of Warsaw, ul. S. Banacha 1, 02-097 Warsaw, Poland;2. Department of Physical Chemistry, Faculty of Chemistry, University of Warsaw, ul. L. Pasteura 1, 02-093 Warsaw, Poland;3. Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, ul. S. Noakowskiego 3, 00-664 Warsaw, Poland;4. Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, ul. Kozielska 4, 01-163 Warsaw, Poland;5. Department of Bioanalysis, Faculty of Pharmacy, Medical University of Warsaw, ul. S. Banacha 1, 02-097 Warsaw, Poland;6. Analytic Centre, University of Life Sciences, ul. J. Ciszewskiego 8, 02-786 Warsaw, Poland;7. Department of Clinical Radiology, Faculty of Medicine, Medical University of Warsaw, ul. S. Banacha 1a, 02-097 Warsaw, Poland |
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| Abstract: | The aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFα) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP). Serum levels of metabolites of arachidonic, eicosapentaenoic and linoleic acids (hydroxyeicosatetraenoic, hydroxyeicosapentaenoic and hydroxyoctadecadienoic acids, respectively), as compounds involved in inflammation and cancer development, were also investigated. Male rats were randomised into dietary groups supplemented with Zn, Se or Fe. Prostate cancer cells were implanted to some rats in each group.The study demonstrated that minerals supplemented with the diet may exert various effects on an organism. Selenium, zinc and iron influence pro-inflammatory cytokine expression, what leads to stimulation of inflammation. They also affect synthesis of arachidonic and linoleic acid metabolites that exert pro-inflammatory action and enable cancer development and metastasis. |
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| Keywords: | Elements Cytokines IL-1 IL-6 TNF Metabolites of fatty acids |
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