Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort |
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| Institution: | 1. Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;2. Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China;3. Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;4. Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;5. Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, Guangxi, China;6. Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China;1. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany;2. School of Health Sciences, Purdue University, West Lafayette, IN, USA;3. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA;4. Department of Neurology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany;5. Institute of Clinical Neuroscience and Medical Psychology, University Hospital Düsseldorf, Meerbusch, Germany;6. Institute for Cognitive Neuroscience, Biopsychology, Ruhr University Bochum, Bochum, Germany;7. Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), Sankt Augustin, Germany;8. Department of Neurology, St. Josef- Hospital, Katholische Kliniken Ruhrhalbinsel, Contilia Gruppe, Essen, Germany;9. Department of Neurology, Sankt Josef Hospital, Bochum, Germany;10. Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany;1. Department of Family Medicine, Faculty of Medicine, Cairo University, Egypt;2. Department of Dermatology, Faculty of Medicine, Cairo University, Egypt;3. Department of Clinical biochemistry and molecular biology, Faculty of Medicine, Cairo University, Egypt;4. Department of Family medicine, Faculty of Medicine, Zagazig University, Egypt;1. Institute of Inorganic Chemistry, Academy of Sciences of the Czech Republic, ?e?, 250 68, Czech Republic;2. Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 40, Prague, Czech Republic;3. Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic;1. McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, K1N 6N5, Canada;2. Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267-0056, United States |
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| Abstract: | BackgroundManganese (Mn) ions play a crucial role in the immune response. The immunotoxicity of Mn is rarely reported compared with the neurotoxicity of Mn.ObjectivesThe purpose of this study was to investigate the associations between chronic Mn exposure and immunological parameters in occupational Mn-exposed workers.MethodsA total of 538 workers were selected from the follow-up of manganese-exposed workers healthy cohort (MEWHC) in 2017. We divided the workers into the low-exposure group and the high-exposure group by the cutoff of the manganese-time weighted average (Mn-TWA) setting at 0.15 mg/m3. We examined serum immunological parameters by the immunoturbidimetric method and leukocyte counts and ratios in blood routine. Then we used the generalized linear model analyses and spline analyses to explore the associations between external exposure of Mn and multiple immunological parameters adjusted for variables. Based on the epidemiological analyses, we used Elisa (enzyme-linked immune sorbent assay) to detect plasma complement C3 of Mn-exposed rats.ResultsIn male workers, the mean value of complement C3 was 1.20 ± 0.16 g/L in the high-exposure group, which was significantly lower as compared to the low-exposure group (1.25 ± 0.18 g/L, P = 0.023). The generalize linear models’ analyses showed that complement C3 value had a significantly negative association with external exposure of Mn included adjustment for variables (β = -0.04, P = 0.035). Moreover, in male rats, the high-exposure group also had a lower level of complement C3 compared with the low-exposure group (P < 0.001). None significant association was observed in immunological parameters among female workers and rats (all P > 0.05).ConclusionsMn exposure from inhalable dust was associated with decreased complement C3 among occupationally Mn-exposed male individuals but not in female workers, which was further confirmed by the rat model. Further research into the possible mechanism of C3 reduction is needed in the future. |
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| Keywords: | Manganese Occupation Immunity Complement C3 |
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