Genetic regulation of glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster |
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| Authors: | Mark W. Steele William J. Young Barton Childs |
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| Affiliation: | (1) Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland;(2) the Harriet Lane Service of the Johns Hopkins Children's Medical and Surgical Center, Baltimore, Maryland;(3) Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland;(4) the Harriet Lane Service of the Johns Hopkins Children's Medical and Surgical Center, Baltimore, Maryland;(5) Present address: Department of Pediatrics, Children's Hospital of Pittsburgh, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;(6) Present address: Department of Anatomy, University of Vermont School of Medicine, Burlington, Vermont |
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| Abstract: | ![]()
Studies on two variants of X-linked enzyme, G6PD, in several inbred and outbred strains of Drosophila melanogaster suggest that (1) there is dosage compensation at this locus; (2) males have 20–33% more activity than females, due to enzyme-deficient eggs in the latter; (3) outcrossing Drosophila strains results in a significant rise in G6PD specific activity in such a way as to suggest the presence of two or more nonlinked loci specific in their effect on G6PD activity (the effect is twice as great in males as it is in females); (4) there is less  A enzyme than B enzyme activity/mg protein in males, but they are equal in females; (5) the presence or absence of X-linked regulators for G6PD could not be ascertained.Aided by National Institutes of Health grants HD 00004, HD00486, and GM 14155. |
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