Comparison of radiation-and chemically-induced dominant lethal mutations in male mice |
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Authors: | U H Ehling |
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Institution: | Institute für Biologie der Gesellschaft für Strahlenforschung, Abteilung für Genetik, Neuherberg bei München Germany |
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Abstract: | Ionizing radiation-induced dominant lethal mutations in all spermatogenic stages. After irradiation of male mice with 200 R the yield of induced mutations in early spermatids was twice the yield in spermatozoa, late spermatids, and spermatocytes. After irradiation with 400 R or 800 R the spermatocytes were the most sensitive stage for the induction of dominant lethal mutations. The frequency of radiation-induced dominant lethal mutations in postspermatogonial stages was dose-dependent. The yield of dominant lethal mutations in spermatogonia was independent of the dose. |
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Keywords: | AET S 2-aminoethylisothiuronium · Br · HBr EMS ethyl methanesulfonate iPMS isopropyl methanesulfonate MMS methyl methanesulfonate PMS n-propyl methanesulfonate |
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