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Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells
Authors:Thériault Jimmy R  Mambula Salamatu S  Sawamura Tatsuya  Stevenson Mary Ann  Calderwood Stuart K
Affiliation:Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21-27 Burlington Avenue, Boston, MA 02215, USA.
Abstract:Extracellular HSP70 has been found to participate in both innate and adaptive immune responses. However, little is known about the molecular mechanisms that mediate this process. Previous reports suggest that HSP70 interacts with antigen presenting cells (APC) through a plethora of surface receptors. In this study, we have examined the relative binding of potential HSP70 receptors and found high affinity binding to LOX-1 but not other structures with a role in HSP70-APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or another c-type lectin family member (DC-SIGN) closely related to LOX-1. In addition to APC, HSP70 can avidly bind to non-APC cell lines, especially those from epithelial or endothelial background.
Keywords:Heat shock protein 70   LOX-1   Toll-like receptor   CD40   Endothelial
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