| 基因组尺度分析和代谢工程策略 |
| |
| 引用本文： | 李宏. 基因组尺度分析和代谢工程策略[J]. 生物信息学, 2012, 10(1): 55-60 |
| |
| 作者姓名： | 李宏 |
| |
| 作者单位： | 重庆工商大学环境与生物工程学院,重庆,400067 |
| |
| 基金项目： | 重庆市科委自然科学基金（No.2003-8093）; 重庆市教委科研基金（No.31916002） |
| |
| 摘 要： | 代谢工程是近年来发展起来的新技术,随着各种组学技术的发展,高通量数据整合方法用于分析细胞的代谢网络,改造代谢途径,以提高目标产物的产量。本文就代谢工程的发展状况,基因组尺度的分析技术,以及代谢工程策略进行了综述。分析了生物信息学和系统生物学方法在代谢途径构建和代谢网络分析中的作用,并就存在的问题和可能的解决途径进行了阐述。
|
| 关 键 词： | 代谢途径 网络分析 基因组尺度 系统生物学 生物信息学 |
Genome-scale analysis and metabolic engineering strategies |
| |
| LI Hong. Genome-scale analysis and metabolic engineering strategies[J]. Chinese Journal of Bioinformatics, 2012, 10(1): 55-60 |
| |
| Authors: | LI Hong |
| |
| Affiliation: | LI Hong(College of Environmental and Biological Engineering,Chongqing Technology and Business University,Chongqing 400067,China) |
| |
| Abstract: | Metabolic engineering is a new technology developed in recent years.With the advance of ＂omics＂ technology,high throughput data integrating analysis is applied in the analysis of intracellular metabolic network and the modification of metabolic pathway in order to increase the yield of the product of interest.We reviewed the development of metabolic engineering,genome-scale analysis techniques,and the strategies of metabolic engineering in this paper.We also analyzed the roles of the genome-scale analysis methods of bioinformatics and system biology in the construction of metabolic pathway and the analysis of intracellular metabolic network,and set forth the existing problems and the soluble approaches. |
| |
| Keywords: | metabolic pathway network analysis genome-scale system biology bioinformatics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
