Synthesis of OSW-1 analogs with modified side chains and their antitumor activities |
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| Authors: | Deng Lehua Wu Hao Yu Biao Jiang Manrong Wu Jiarui |
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| Institution: | State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. |
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| Abstract: | Four analogs of OSW-1 (1-4) with modified side chains on the steroidal skeleton were synthesized following modification of our previous route for the total synthesis of OSW-1. Testing of the analogs against growth of tumor cells demonstrated that the 22-one function and the full length of the side chain of OSW-1 were not required for the antitumor action of OSW-1. |
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