2D proteome analysis initiates new Insights on the Salmonella Typhimurium LuxS protein |
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| Authors: | Gwendoline Kint Kathleen AJ Sonck Geert Schoofs David De Coster Jos Vanderleyden Sigrid CJ De Keersmaecker |
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| Affiliation: | (1) Centre of Microbial and Plant Genetics, K. U. Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium |
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| Abstract: | Background Quorum sensing is a term describing a bacterial communication system mediated by the production and recognition of small signaling molecules. The LuxS enzyme, catalyzing the synthesis of AI-2, is conserved in a wide diversity of bacteria. AI-2 has therefore been suggested as an interspecies quorum sensing signal. To investigate the role of endogenous AI-2 in protein expression of the Gram-negative pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), we performed a 2D-DIGE proteomics experiment comparing total protein extract of wildtype S. Typhimurium with that of a luxS mutant, unable to produce AI-2. |
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