Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection |
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| Institution: | 1. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, Guizhou Medical University, Guiyang 550025, Guizhou, China;2. The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China;1. Dept. Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands;2. Dept. Biochemistry & Cell Biology, Fac. Veterinary Medicine, Utrecht University, Utrecht, The Netherlands;1. The First Department of Neurology, Rizhao People’s Hospital, Rizhao, 276800, Shandong, China;2. Department of Neurology, Zhucheng People’s Hospital, Zhucheng, 262200, Shandong, China;3. Department of Neurology, Shanxian Central Hospital, Heze, 274300, Shandong, China;1. Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK;2. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK;1. Parasite Cell Biology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia;2. School of Veterinary Sciences, The University of Queensland, Gatton, 4343, Australia;3. School of Medical Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia;4. Division of Mycobacterial Research, National Institute for Medical Research, London, NW7 1AA, UK;5. Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia |
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| Abstract: | Extracellular vesicles are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterised the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs. Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection. |
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| Keywords: | Extracellular vesicle microRNA cargo Macrophage |
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