The inhibition of the avian myeloblastosis virus DNA polymerase by poly(U) fractions of varying chain length |
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| Authors: | R J Erickson B Janik R G Sommer |
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| Affiliation: | Molecular Biology Department Miles Laboratories, Inc. Elkhart, IN 46514 USA |
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| Abstract: | Poly(U) is an effective inhibitor of the RNA-dependent DNA polymerase of oncornaviruses. This inhibition was found to be dependent on the chain length of the inhibitory polymer. The inhibitory effect drops sharply at chain lengths below approximately 200 nucleotide residues per poly(U) molecule. The results suggest that poly(U) exerts an inhibitory effect by competing for the template binding site on the viral DNA polymerase. |
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