Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases |
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| Authors: | Shamshad Cockcroft |
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| Affiliation: | Department of Neuroscience, Physiology and Pharmacology, Gower Street, University College London, London WC1E 6BT, UK |
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| Abstract: | Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane. |
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| Keywords: | PLD, phospholipase D ARF, ADP ribosylation factor PIP5K or PIP 5-kinase, Phosphatidylinositol 4-phosphate 5-kinase PIP4K, phosphatidylinositol 5-phosphate 4-kinase PI, phosphatidylinositol PC, phosphatidylcholine PI(4,5)P2, phosphatidylinositol(4,5)bisphosphate PS, phosphatidylserine PE, phosphatidylethanolamine TG, triacylglycerol PAP-1, phosphatidate phosphohydrolase DAG, diacylglycerol PKC, Protein kinase C |
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