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Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance |
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| Authors: | Silvia Buroni Maria R Pasca Ronald S Flannagan Silvia Bazzini Anna Milano Iris Bertani Vittorio Venturi Miguel A Valvano Giovanna Riccardi |
| Affiliation: | (1) Department of Genetics and Microbiology, University of Pavia, Pavia, 27100, Italy;(2) Infectious Diseases Research Group, Department of Microbiology and Immunology, Siebens-Drake Research Institute, University of Western Ontario, London, ON, N6A 5C1, Canada;(3) Bacteriology Group, International Center for Genetic Engineering Biotechnology, Padriciano 99, Trieste, 34012, Italy |
| Abstract: | BackgroundBurkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis. These bacteria demonstrate a high-level of intrinsic antibiotic resistance to most clinically useful antibiotics complicating treatment. We previously identified 14 genes encoding putative Resistance-Nodulation-Cell Division (RND) efflux pumps in the genome of B. cenocepacia J2315, but the contribution of these pumps to the intrinsic drug resistance of this bacterium remains unclear. |
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