Mechanisms of stepping rhythm formation in decerebrated and chronic spinal cats under epidural stimulation |
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Authors: | Bogacheva I N Nikitin O A Musienko P E Savokhin A A Gerasimenko Yu P |
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Institution: | 1.Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia ; |
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Abstract: | A study was made of the stepping pattern formation in decerebrated and in chronic spinal cats during epidural stimulation
(ES). The hindlimb stepping performance depended on the parameters of ES and afferent input. At non-optimal ES parameters,
no stepping was induced, only muscle reflexes followed the stimulation rhythm. Optimized ES (3–5 Hz, 50–100 μA for decerebrated
and 20–30 Hz, 150–250 μA for spinal cats) evoked coordinated stepping movements at a natural rate (0.8–1 Hz) accompanied by
electromyographic burst activity of the corresponding muscles. In decerebrated cats, the bursts are formed owing to modulation
of early responses and the late polysynaptic activity. In chronic spinal cats, this process is mainly due to amplitude modulation
of the early responses. Formation of the stepping pattern in decerebrated cats involves spinal interneurons responsible for
the polysynaptic activity, which allows its correction based on processing the afferent signals. Activation of this system
in chronic spinal cats can be realized by afferent stimulation alone, without ES. |
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