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Microbial hydroxylation of progesterone with Acremonium strictum |
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| Authors: | Faramarzi Mohammad Ali Tabatabaei Yazdi Mojtaba Amini Mohsen Zarrini Gholamreza Shafiee Abbas |
| Affiliation: | Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174, Tehran, Iran. |
| Abstract: | Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone. |
| Keywords: | Biotransformation Microbial hydroxylation Progesterone Steroid Acremonium strictum |
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