Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolyl‐thiazolidine‐2,4‐dione compounds |
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| Authors: | Oya Bozda?‐Dündar Selen Gürkan Hassan Y Aboul‐Enein Irena Kruk Aleksandra K?adna |
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| Institution: | 1. Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tando?an, Ankara, Turkey;2. Pharmaceutical and Medicinal Chemistry Department, The Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, Egypt;3. Institute of Physics, Szczecin University of Technology, Al. Piastów 48/49, 70‐311 Szczecin, Poland;4. Department of Medical History and Ethics, Pomeranian Medical University, Al. Powstancow Wielkopolskich 72, 70‐111 Szczecin, Poland |
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| Abstract: | The antioxidant behavior of a series of new synthesized substituted thiazolyl‐thiazolidine‐2,4‐dione compounds (TZDs) was examined using chemiluminescence and electron paramagnetic resonance spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐N‐oxide (DMPO) was used as the spin trap. The reactivity of TZDs with superoxide anion radical (O ) and hydroxyl radical (HO?) was evaluated using potassium superoxide/18‐crown‐6 ether dissolved in dimethylsulfoxide, and the Fenton‐like reaction (Fe2+ + H2O2), respectively. The results showed that TZDs efficiently inhibited light emission from the O generating system at a concentration of 0.05–1 mmol L?1 (5–94% reductions were found at 1 mmol L?1 concentration). The TZD compounds showed inhibition of HO?‐dependent DMPO–OH spin adduct formation from DMPO (the amplitude decrease ranged from 8 to 82% at 1 mmol L?1 concentration). The findings showed that examined TZDs had effective activities as radical scavengers. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | thiazolyl‐thiazolidine‐2 4‐dione compounds superoxide radical hydroxyl radical chemiluminescene electron paramagnetic resonance |
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