Magnetic force microscopy of iron oxide nanoparticles and their cellular uptake |
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| Authors: | Yu Zhang Mo Yang Mihrimah Ozkan Cengiz S Ozkan |
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| Institution: | 1. Dept. of Mechanical Engineering, University of California Riverside, Riverside, CA 92521;2. Dept. of Health Technology and Informatics, the Hong Kong Polytechnic University, Hong Kong, China;3. Dept. of Electrical Engineering, University of California Riverside, Riverside, CA 92521 |
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| Abstract: | Magnetic force microscopy has the capability to detect magnetic domains from a close distance, which can provide the magnetic force gradient image of the scanned samples and also simultaneously obtain atomic force microscope (AFM) topography image as well as AFM phase image. In this work, we demonstrate the use of magnetic force microscopy together with AFM topography and phase imaging for the characterization of magnetic iron oxide nanoparticles and their cellular uptake behavior with the MCF7 carcinoma breast epithelial cells. This method can provide useful information such as the magnetic responses of nanoparticles, nanoparticle spatial localization, cell morphology, and cell surface domains at the same time for better understanding magnetic nanoparticle‐cell interaction. It would help to design magnetic‐related new imaging, diagnostic and therapeutic methods. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 |
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| Keywords: | magnetic force microscopy cancer cell iron oxide nanoparticle cell culture MCF7 |
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