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Allostery in Its Many Disguises: From Theory to Applications
Authors:Shoshana J. Wodak  Emanuele Paci  Nikolay V. Dokholyan  Igor N. Berezovsky  Amnon Horovitz  Jing Li  Vincent J. Hilser  Ivet Bahar  John Karanicolas  Gerhard Stock  Peter Hamm  Roland H. Stote  Jerome Eberhardt  Yassmine Chebaro  Annick Dejaegere  Marco Cecchini  Jean-Pierre Changeux  Peter G. Bolhuis  Tom McLeish
Affiliation:1. VIB-VUB Centre for Structural Biology, Brussels, Belgium;2. Astbury Centre, University of Leeds, Leeds, UK;3. Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;5. Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel;6. Departments of Biology and T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, USA;7. School of Medicine, University of Pittsburgh, Pittsburgh, USA;8. Fox Chase Cancer Center, Philadelphia, USA;9. Biomolecular Dynamics, Institute of Physics, Albert Ludwigs University, Freiburg, Germany;10. Department of Chemistry, University of Zurich, Zurich, Switzerland;11. Department of Integrative Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France;12. Institut de Chimie de Strasbourg, UMR7177 CNRS & Université de Strasbourg, Strasbourg, France;13. Institut Pasteur & Collège de France, Paris, France;14. van ''t Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Amsterdam, Netherlands;15. Physics Department, Università di Trento and INFN-TIFPA, Trento, Italy;16. Institute of Physics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;17. Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA;18. Instituto de Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91501-970, Brazil;19. Structure Design and Informatics, Sanofi R&D, Chilly-Mazarin, France;20. École Normale Supérieure de Lyon, Université de Lyon, CNRS, Université Claude Bernard Lyon 1, Lyon, France;21. Department of Chemistry and Biochemistry, University of California, San Diego, USA;22. Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland;23. Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS) and Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany;24. Leibniz-Institute for Food Systems Biology, Technical University of Munich, Munich, Germany;25. Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture Food and Environment, The Hebrew University, Jerusalem, Israel;26. Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, USA;27. Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794, USA;28. Department of Physics, University of York, York, UK;29. Departments of Pharmacology and Biochemistry & Molecular Biology, Penn State Medical Center, Hershey, PA, USA;30. Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;31. Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany;32. Department of Bioengineering, University of California Riverside, CA 92507, USA
Abstract:
Keywords:Allostery  protein conformational changes  regulation  protein function  molecular dynamics  elastic network models  signal transduction  allosteric drugs  allosteric switches  allosteric material  energy landscape
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