Cycloartane Triterpenes from Dikamali,the Gum Resin of Gardenia gummifera and Gardenia lucida |
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| Authors: | Olaf Kunert Gandhe Sreekanth Gummadi Sreedhar Babu Belvotagi Venkat Rao Adavi Rao Marupaka Radhakishan Bobbala Ravi Kumar Robert Saf Achanta Venkata Narasimha Appa Rao Wolfgang Schühly |
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| Affiliation: | 1. Institute of Pharmaceutical Sciences, Karl‐Franzens‐University Graz, Universit?tsplatz 4, AT‐8010 Graz (phone: +43‐316‐3805527;2. fax: +43‐316‐3809860);3. University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506?009, A.P., India;4. Government Polytechnic for Women, Warangal – 506?009, A.P., India;5. Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 16, AT‐8010 Graz |
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| Abstract: | We report on the chemical investigation of dikamali gum, which is the resin of Gardenia gummifera and G. lucida (Rubiaceae). Six new cycloartane triterpenes, dikamaliartanes A–F ( 1 – 6 , resp.), together with a known flavonoid ( 7 ), were isolated and identified by NMR spectroscopy. All six cycloartanes are characterized by an open A‐ring with a free COOH group at C(3). In four of them, the C‐atoms C(23)–C(27) form a 4‐methylfuran‐2‐yl moiety. Bacterial assays using Staphylococcus aureus, Candida albicans, and Mycobacteria have been carried out but did not reveal significant activity. |
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| Keywords: | Dikamali Gardenia gummifera Gardenia lucida Cycloartane triterpenes Triterpenes Dikamaliartanes |
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