Cerebral glucose transporter: The possible therapeutic target for ischemic stroke |
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| Institution: | 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;2. Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, China;1. First Department of Internal Medicine, Medical School, University of Athens, Laikon Hospital, Athens, Greece;2. First Department of Critical Care, Medical School, University of Athens, Evangelismos Hospital, Athens, Greece;3. Pediatric Intensive Care Unit, University Hospital, University of Crete, Heraklion, Greece;1. Reconstructive and Aesthetic Plastic Surgery School, Department of Medical Biotechnology and Translational Medicine BIOMETRA, Plastic Surgery Unit, Humanitas Clinical and Research Center, University of Milan, Via Manzoni 56, 20089, Rozzano, Milan, Italy;2. Reconstructive and Aesthetic Plastic Surgery School, MultiMedica Holding S.P.A., Plastic Surgery Unit, University of Milan, Sesto San Giovanni, Milan, Italy;3. Clinica San Carlo, Plastic Surgery Unit, Via Ospedale 21, 20037, Paderno Dugnano, Milan, Italy;1. Department of Pediatrics, Yuhuang Ding Hospital, Yantai, Shandong 264000, China;2. Health Care Section, Zhifu Hospital, Yantai, Shandong 264000, China;1. Department of Neurology, Chinese PLA General Hospital, Beijing, China;2. Department of Radiology, Chinese PLA General Hospital, Beijing, China |
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| Abstract: | Hyperglycemia is considered to be associated with poor outcomes of ischemic stroke. However, it is controversial about the blood glucose-lowering therapy in patients with stroke. According to the current reports, hyperglycemia is an indicator of severe stroke and cannot increase cerebral glucose content but promotes further ischemia in brain. Consequently, cerebral glucose control is significant to maintain the energy homeostasis. Compared with blood glucose level, the cerebral glucose content, controlled by glucose transporters (GLUTs), is more directly and important to maintain the energy supply in brain, especially to the patients with ischemic stroke. Some active materials, such as Glucagon-like peptide-1, progesterone, tPA and N-acetylcysteine, have been found to ameliorate ischemic stroke by regulating GLUTs expression. Therefore, this review discusses the significance of cerebral glucose level and GLUTs. Additionally, cerebral GLUTs and their actions in ischemic stroke are detailed in order to promote research on GLUTs as a possible therapeutic target for ischemic stroke. |
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| Keywords: | Ischemic stroke Hyperglycemia Cerebral glucose Glucose transporter |
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