The metabolism of metals in rat placenta |
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| Authors: | Alberto Mas Bibudhendra Sarkar |
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| Institution: | 1. Research Institute, The Hospital for Sick Children, M5G 1X8, Toronto, Ontario
2. The Department of Biochemistry, University of Toronto, M5S 1A8, Toronto, Ontario, Canada
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| Abstract: | The status and transfer of metals across the rat placenta were studied by subcellular and molecular fractionations of this organ at 2 and 24 h after iv injection of radiolabeled metals. The soluble and nuclear fractions showed higher contents of copper and zinc, whereas most of the nickel was associated with the soluble fraction. Cadmium was almost evenly distributed between the microsomal and nuclear fractions. Gel filtration of the soluble fractions showed nickel associated with an unknown low molecular weight form; zinc with high molecular weight proteins; copper with metallothionein, ceruloplasmin, and high molecular weight proteins; and cadmium with high molecular weight proteins and metallothionein. |
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