Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats |
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Authors: | Robert E Hruska Karen T Pitman Ellen K Silbergeld Lynn M Ludmer |
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Institution: | Neurotoxicology Section National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, MD 20205, USA |
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Abstract: | Administration of prolactin to adult male rats, by s.c. injection, significantly increases the density of the striatal dopamine (DA) receptors, without altering the apparent affinity of the receptors for 3H]spiroperidol. Larger doses of prolactin are required to increase the density of the striatal DA receptors in hypophysectomized rates compared to normal rats. These results suggest that prolactin might be the common mediator of the increase in striatal DA receptor density produced by either estrogen or haloperidol administration. Monitoring and/or altering prolactin levels might be informative in neurologic or psychiatric disorders involving striatal DA neurotransmission. |
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Keywords: | Correspondence to: R E H NIH Bldg 9 Rm 1E127 Bethesda MD 20205 USA |
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