Effect of phencyclidine on plasma corticosterone in mice |
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| Authors: | William O. Boggan Cleatus J. Wallis Michael H. Owens |
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| Affiliation: | Department of Psychiatry and Behavioral Sciences medical University of South Carolina Charleston, South Carolina 29425, USA |
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| Abstract: | Phencyclidine produced a dose dependent increase in plasma corticosterone when administered to ovariectomized C57BL/6J mice. This effect was blocked by pretreatment of the animals with dexamethasone. The plasma corticosterone concentration after PCP remained elevated after the concentration of PCP observed in plasma and brain tissue began to decline. These data demonstrate a stress-like hormonal effect of PCP in mice which appears to be a result of an action of PCP at the pituitary, hypothalamus, or higher. |
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