Bombesin-like immunoreactivity in developing human lung |
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| Authors: | N.S. Track E. Cutz |
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| Affiliation: | Departments of Surgery, Clinical Biochemistry and Pathology, University of Toronto, Mt. Sinai Hospital, and The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8 |
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| Abstract: | Bombesin-like immunoreactivity (BLI) was detected by a specific radioimmunoassay in extracts of 15 human lungs from fetuses, neonates, infants and children. A higher concentration of lung BLI was found in the fetal/neonatal group (2053.2 ± 316.3 ng bombesin/g protein, n=6) compared to the infant/children group (416.3 ± 64.3 ng/g, n=9). The peaking of BLI in lungs during the fetal/neonatal period suggests an important function for this peptide in intrauterine life and neonatal adaptation. |
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